Commas after interjections
 
A comma is used after an introductory expression such as yes, indeed or absolutely.
 

Commas after Interjections

Expressions such as yes, no and indeed (usually at the start of a sentence) are known as interjections. Interjections can be followed by a comma.

Examples:

Well, the rain has played its part in the outcome of this match.

Yes, she will apologise.

Absolutely, a fifth of all the students live in the village.

If an interjection appears mid sentence, offset it with commas. Likewise, if it appears at the end, offset it with a comma.

Examples:

The office can handle, well, four hundred applications per day.

It's cold, indeed.
 
MILDER WITH A COMMA 

An interjection can also be followed by an exclamation mark, but this gives the interjection more impact. (Consider the difference between No! and No,.)

USUALLY NOT IN BUSINESS WRITING 

Interjections are usually only used when spoken words are being quoted. You should avoid them in business writing.
 

See also:

What are interjections?
Commas after a sentence introductions
Commas after a transitional phrase
Commas before conjunctions (and, or, but)
Commas for parenthesis
Commas in lists
Commas with a long subject
Commas with numbers
Commas with quotation (speech) marks
Commas with the vocative case
Commas with Dear, Hello, and Hi
List of easily confused words


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